Protein name:
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 ;
Alternative:
JmjC domain-containing protein 6 ;Histone arginine demethylase JMJD6 ;Lysyl-hydroxylase JMJD6 ;Jumonji domain-containing protein 6 ;Phosphatidylserine receptor (Protein PTDSR) ;Peptide-lysine 5-dioxygenase JMJD6 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65.
Function:
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
Subcellular Location:
Nucleus
nucleoplasm
Nucleus
nucleolus
Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Protein Attributes:
50:
MNHKSKKRIR | EAKRSARPEL | KDSLDWTRHN | YYESYPLSPA | AVPDNVERAD |
100:
ALQLSVKEFV | ERYERPYKPV | VLLNAQEGWS | AQEKWTLERL | KRKYRNQKFK |
150:
CGEDNDGYSV | KMKMKYYIEY | MESTRDDSPL | YIFDSSYGEH | PKRRKLLEDY |
200:
KVPKFFTDDL | FQYAGEKRRP | PYRWFVMGPP | RSGTGIHIDP | LGTSAWNALV |
250:
QGHKRWCLFP | TNTPRELIKV | TREEGGNQQD | EAITWFNVIY | PRTQLPTWPP |
300:
EFKPLEILQK | PGETVFVPGG | WWHVVLNLDT | TIAITQNFAS | STNFPVVWHK |
350:
TVRGRPKLSR | KWYRILKQEH | PELAVLADAV | DLQESTGIAS | DSSSDSSSSS |
400:
SSSSSDSDSE | CESGSEGDGT | THRRKKRRTC | SMVGNGDTTS | QDDCVSKERS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Chicken
ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .